Product Description: N-alpha-acetyltransferase 15, NatA auxiliary subunit, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.1.88 (Transferred entry: 2.3.1.254, 2.3.1.255, 2.3.1.256, 2.3.1.257, 2.3.1.258and 2.3.1.259)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Process | GO:0017196 | N-terminal peptidyl-methionine acetylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.46 | 0.80 |
| Trophozoite | expressed | 0.59 | 0.67 |
| Schizont | expressed | 0.71 | 0.68 |
| Gametocyte | expressed | 0.36 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1244100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.158 | MFS: -3.284 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4Y9
"Best" AlphaFill ligand hit: 1YJ (n-[4-({[(6r)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid, Local RMSD=5.07) with 4YFY (Global RMSD=14.16)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.88 | peptide alpha-N-acetyltransferase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101670
Most Similar Human Ortholog: Q9BXJ9
TM-align score: 0.83 | RMSD: 3.55
Seq Identity: 0.24 | Length: 787 / 1296
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164134 | N-alpha-acetyltransferase 15, NatA auxiliary subunit |
| ENSG00000172766 | N-alpha-acetyltransferase 16, NatA auxiliary subunit |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 73 | 34 | 82 |
| disruptive | 36 | 146 | 92 | 212 |
| missense | 25 | 139 | 90 | 192 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 136 | 45 | 96 |
| disruptive | 64 | 356 | 161 | 381 |
| missense | 47 | 306 | 136 | 253 |
PlasmoDB Total SNPs: 276
Non-coding: 160 | Synonymous: 78 | Nonsynonymous: 36 | Stop Codon: 2
Protein Length: 1296 | Molecular Weight (kDa): 154.903
UniProt ID(s): Q8I4Y9
PDB ID(s): None
Isoelectric Point: 7.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| InterPro | IPR019734 | Tetratricopeptide repeat |
| InterPro | IPR021183 | N-terminal acetyltransferase A, auxiliary subunit |
| PFam | PF12569 | N-terminal acetyltransferase A, auxiliary subunit |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |