About Gene List

PF3D7_1244400

Genome location: Pf3D7_12_v3:1,859,656..1,866,652(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:1990904 ribonucleoprotein complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 1.93 0.37
Trophozoite possibly expressed 1.37 0.37
Schizont expressed 1.00 0.52
Gametocyte not expressed 0.66 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1244400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.149 | MFS: -2.897 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Y7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533171

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 79 33 93
disruptive 68 215 96 272
missense 45 183 86 228

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 23 144 65 105
disruptive 115 445 178 370
missense 71 364 142 266

PlasmoDB Total SNPs: 292

Non-coding: 41 | Synonymous: 89 | Nonsynonymous: 162 | Stop Codon: 0

Protein Information

Protein Length: 1335 | Molecular Weight (kDa): 159.505

UniProt ID(s): Q8I4Y7

PDB ID(s): None

Isoelectric Point: 8.63

Protein Domain Annotations:

Source Family ID Description
InterPro IPR035979 RNA-binding domain superfamily
PFam N/A N/A
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895