Genome location: Pf3D7_12_v3:1,864,229..1,866,661(-)
Genome classification: Core
Product Description: PIMMS57 protein
SignalP Peptide: MGKCDFFIFLPIFFFVLIWYVHYVLG
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005737 | cytoplasm |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.17 | 0.91 |
| Trophozoite | not expressed | 0.03 | 0.98 |
| Schizont | not expressed | 0.04 | 0.98 |
| Gametocyte | not expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1244500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.987 | MFS: -1.648 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1457700)
Modification: Tagged | RMgm-5214
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4Y6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 36 | 21 | 51 |
| disruptive | 37 | 110 | 65 | 152 |
| missense | 21 | 89 | 61 | 136 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 60 | 32 | 72 |
| disruptive | 57 | 226 | 122 | 242 |
| missense | 34 | 188 | 96 | 188 |
PlasmoDB Total SNPs: 0
Non-coding: 0 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 810 | Molecular Weight (kDa): 94.626
UniProt ID(s): Q8I4Y6
PDB ID(s): None
Isoelectric Point: 9.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27083421 | Identification of three ookinete-specific genes and evaluation of theirtransmission-blocking potentials in Plasmodium berghei. | Zheng W, Kou X, ..., Cui L | 10.1016/j.vaccine.2016.04.011 |
| 33791240 | Identification of Three Novel Plasmodium Factors Involved in Ookinete to OocystDevelopmental Transition. | Ukegbu CV, Christophides GK, Vlachou D | 10.3389/fcimb.2021.634273 |