Genome location: Pf3D7_12_v3:1,868,217..1,870,149(-)
Genome classification: Core
Product Description: ADP-ribosylation factor GTPase-activating protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Function | GO:0003677 | DNA binding |
| Function | GO:0005096 | GTPase activator activity |
| Process | GO:0048205 | COPI coating of Golgi vesicle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.37 | 0.81 |
| Trophozoite | expressed | 0.51 | 0.70 |
| Schizont | expressed | 0.62 | 0.63 |
| Gametocyte | expressed | 0.44 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1244600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -2.765 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4Y5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102808
Most Similar Human Ortholog: E5RIU2
TM-align score: 0.94 | RMSD: 0.76
Seq Identity: 0.44 | Length: 78 / 332
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101199 | ADP ribosylation factor GTPase activating protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 15 | 12 | 22 |
| disruptive | 2 | 11 | 9 | 35 |
| missense | 2 | 11 | 9 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 40 | 11 | 19 |
| disruptive | 6 | 39 | 33 | 96 |
| missense | 5 | 33 | 27 | 60 |
PlasmoDB Total SNPs: 57
Non-coding: 40 | Synonymous: 11 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 332 | Molecular Weight (kDa): 37.288
UniProt ID(s): Q8I4Y5
PDB ID(s): 3SUB
Isoelectric Point: 5.42
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001164 | Arf GTPase activating protein |
| InterPro | IPR037278 | ARFGAP/RecO-like zinc finger |
| PFam | PF01412 | Arf GTPase activating protein |
| Superfamily | SSF57863 | ARFGAP/RecO-like zinc finger |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22102228 | Structure of the catalytic domain of Plasmodium falciparum ARF GTPase-activatingprotein (ARFGAP). | Cook WJ, Senkovich O, Chattopadhyay D | 10.1107/S1744309111032507 |
| 28288121 | A genetic system to study Plasmodium falciparum protein function. | Birnbaum J, Flemming S, ..., Spielmann T | 10.1038/nmeth.4223 |
| 32144363 | Detection of the in vitro modulation of Plasmodium falciparum Arf1 by Sec7 andArfGAP domains using a colorimetric plate-based assay. | Swart T, Khan FD, ..., Hoppe HC | 10.1038/s41598-020-61101-3 |