PF3D7_1244700

Genome location: Pf3D7_12_v3:1,870,456..1,873,215(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.13	0.58
Trophozoite	expressed	0.66	0.65
Schizont	expressed	0.84	0.56
Gametocyte	expressed	0.97	0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1244700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.563 | MFS: -2.744 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Y4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148527

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	13	4	9
disruptive	4	16	11	44
missense	3	15	9	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	19	9	13
disruptive	21	64	32	66
missense	7	46	22	37

PlasmoDB Total SNPs: 166

Non-coding: 147 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 222 | Molecular Weight (kDa): 26.303

UniProt ID(s): Q8I4Y4

PDB ID(s): None

Isoelectric Point: 10.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026766	Protein FAM133
PFam	N/A	N/A
Superfamily	N/A	N/A