About Gene List

PF3D7_1244800

Genome location: Pf3D7_12_v3:1,872,831..1,876,270(-)

Genome classification: Core

Function and Localization

Product Description: translation machinery-associated protein 46, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol
Component GO:0005634 nucleus
Process GO:0002181 cytoplasmic translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.25 0.87
Trophozoite expressed 0.36 0.78
Schizont expressed 0.04 0.98
Gametocyte expressed 0.22 0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1244800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.52 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1458000)

  • Relative Growth Rate: 0.50 ± 0.07
  • Confidence: 6.76

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1458000)

Modification: Disrupted | RMgm-4025

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Y3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103017

Most Similar Human Ortholog: F8WF67

TM-align score: 0.45 | RMSD: 2.90

Seq Identity: 0.47 | Length: 49 / 335

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000065548 zinc finger CCCH-type containing 15

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 14 8 26
disruptive 2 12 4 31
missense 2 12 4 29

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 33 17 22
disruptive 5 43 33 78
missense 4 29 26 53

PlasmoDB Total SNPs: 126

Non-coding: 114 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 335 | Molecular Weight (kDa): 39.693

UniProt ID(s): Q8I4Y3

PDB ID(s): None

Isoelectric Point: 5.25

Protein Domain Annotations:

Source Family ID Description
InterPro IPR032378 ZC3H15/TMA46 family, C-terminal
PFam PF16543 ZC3H15/TMA46 family, C-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596