About Gene List

PF3D7_1244900

Genome location: Pf3D7_12_v3:1,875,531..1,880,492(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.47 0.79
Trophozoite expressed 0.62 0.65
Schizont possibly expressed 0.29 0.83
Gametocyte expressed 0.48 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1244900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: -3.201 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Y2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532915

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 28 13 44
disruptive 25 85 46 138
missense 21 73 43 115

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 62 21 69
disruptive 55 208 85 219
missense 34 167 61 139

PlasmoDB Total SNPs: 252

Non-coding: 199 | Synonymous: 37 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 763 | Molecular Weight (kDa): 92.83

UniProt ID(s): Q8I4Y2

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094