About Gene List

PF3D7_1245200

Genome location: Pf3D7_12_v3:1,887,812..1,892,853(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.05 0.97
Trophozoite expressed 0.40 0.76
Schizont expressed 0.06 0.96
Gametocyte possibly expressed 0.44 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1245200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -3.227 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4X9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532839

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 26 72 37 96
disruptive 60 198 120 259
missense 52 182 106 222

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 35 126 77 98
disruptive 91 447 183 354
missense 72 368 157 260

PlasmoDB Total SNPs: 244

Non-coding: 19 | Synonymous: 132 | Nonsynonymous: 86 | Stop Codon: 7

Protein Information

Protein Length: 1482 | Molecular Weight (kDa): 180.009

UniProt ID(s): Q8I4X9

PDB ID(s): None

Isoelectric Point: 9.58

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097