Product Description: 50S ribosomal protein L3, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.15 | 0.92 |
| Trophozoite | expressed | 0.39 | 0.76 |
| Schizont | expressed | 0.16 | 0.90 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1245400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.277 | MFS: -2.703 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1458600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4X7
"Best" AlphaFill ligand hit: LPA (lipoic acid, Local RMSD=23.37) with 5T8U (Global RMSD=22.31)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100949
Most Similar Human Ortholog: D6RC14
TM-align score: 0.93 | RMSD: 1.17
Seq Identity: 0.27 | Length: 153 / 341
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000114686 | mitochondrial ribosomal protein L3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 11 | 24 |
| disruptive | 2 | 11 | 14 | 29 |
| missense | 2 | 11 | 12 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 46 | 8 | 24 |
| disruptive | 7 | 35 | 16 | 59 |
| missense | 4 | 22 | 12 | 47 |
PlasmoDB Total SNPs: 64
Non-coding: 56 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 1
Protein Length: 341 | Molecular Weight (kDa): 39.766
UniProt ID(s): Q8I4X7
PDB ID(s): None
Isoelectric Point: 10.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000597 | Ribosomal protein L3 |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR019927 | Ribosomal protein L3, bacterial/organelle-type |
| PFam | PF00297 | Ribosomal protein L3 |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31339607 | Identification of the Toxoplasma gondii mitochondrial ribosome, andcharacterisation of a protein essential for mitochondrial translation. | Lacombe A, Maclean AE, ..., Sheiner L | 10.1111/mmi.14357 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |