PF3D7_1245500

Genome location: Pf3D7_12_v3:1,896,842..1,899,867(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	not expressed	0.35	0.80
Schizont	not expressed	0.59	0.67
Gametocyte	possibly expressed	0.52	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1245500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.472 | MFS: -2.662 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1458700)

Relative Growth Rate: 0.77 ± 0.21
Confidence: 4.53

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1458700)

Modification: Disrupted | RMgm-4028

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A322

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533748

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	24	8	27
disruptive	5	33	26	72
missense	5	30	24	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	50	22	27
disruptive	24	107	44	104
missense	12	82	32	76

PlasmoDB Total SNPs: 276

Non-coding: 233 | Synonymous: 26 | Nonsynonymous: 15 | Stop Codon: 2

Protein Information

Protein Length: 460 | Molecular Weight (kDa): 56.209

UniProt ID(s): A0A144A322

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A