Genome location: Pf3D7_12_v3:1,908,149..1,909,764(+)
Genome classification: Core
Product Description: epsin-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030125 | clathrin vesicle coat |
| Component | GO:0005768 | endosome |
| Component | GO:0043231 | intracellular membrane-bounded organelle |
| Component | GO:0005886 | plasma membrane |
| Component | GO:0005802 | trans-Golgi network |
| Function | GO:0035650 | AP-1 adaptor complex binding |
| Function | GO:0030276 | clathrin binding |
| Function | GO:0005543 | phospholipid binding |
| Process | GO:0006897 | endocytosis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.65 | 0.72 |
| Trophozoite | expressed | 0.44 | 0.74 |
| Schizont | expressed | 0.24 | 0.86 |
| Gametocyte | expressed | 0.67 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1245800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.673 | MFS: -3.106 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4X4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103058
Most Similar Human Ortholog: J3QLN2
TM-align score: 0.75 | RMSD: 1.58
Seq Identity: 0.30 | Length: 79 / 431
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000063245 | epsin 1 |
| ENSG00000072134 | epsin 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 29 | 13 | 31 |
| disruptive | 22 | 58 | 22 | 76 |
| missense | 19 | 46 | 19 | 61 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 53 | 16 | 33 |
| disruptive | 41 | 123 | 59 | 126 |
| missense | 30 | 92 | 55 | 70 |
PlasmoDB Total SNPs: 145
Non-coding: 90 | Synonymous: 29 | Nonsynonymous: 25 | Stop Codon: 1
Protein Length: 431 | Molecular Weight (kDa): 49.718
UniProt ID(s): Q8I4X4
PDB ID(s): None
Isoelectric Point: 10.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008942 | ENTH/VHS |
| InterPro | IPR013809 | ENTH domain |
| PFam | PF01417 | ENTH domain |
| Superfamily | SSF48464 | ENTH/VHS |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28430827 | Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptryand microneme proteins and in parasite division. | Venugopal K, Werkmeister E, ..., Marion S | 10.1371/journal.ppat.1006331 |