PF3D7_1245900

Genome location: Pf3D7_12_v3:1,910,557..1,912,208(+)

Genome classification: Core

Function and Localization

Product Description: ankyrin-repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.16	0.92
Trophozoite	expressed	0.23	0.86
Schizont	possibly expressed	0.02	0.99
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1245900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.988 | MFS: -2.179 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4X3

"Best" AlphaFill ligand hit: PNM (open form - penicillin g, Local RMSD=0.17) with 5CED (Global RMSD=2.58)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109437

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	14	10	20
disruptive	4	24	17	47
missense	3	24	17	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	35	12	14
disruptive	11	57	32	70
missense	7	52	28	55

PlasmoDB Total SNPs: 56

Non-coding: 30 | Synonymous: 18 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 311 | Molecular Weight (kDa): 36.442

UniProt ID(s): Q8I4X3

PDB ID(s): None

Isoelectric Point: 4.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR036770	Ankyrin repeat-containing domain superfamily
PFam	PF12796	Ankyrin repeat-containing domain
Superfamily	SSF48403	Ankyrin repeat-containing domain superfamily