PF3D7_1246000

Genome location: Pf3D7_12_v3:1,912,457..1,914,595(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.04	0.97
Gametocyte	expressed	0.34	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1246000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.145 | MFS: -3.297 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1459100)

Relative Growth Rate: 1.00 ± 0.10
Confidence: 5.91

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1459100)

Modification: Disrupted | RMgm-4029

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4X2

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.98) with 6JWQ (Global RMSD=20.28)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103482

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	21	21	31
disruptive	14	26	14	32
missense	13	24	13	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	54	24	34
disruptive	22	59	30	80
missense	18	50	25	63

PlasmoDB Total SNPs: 116

Non-coding: 69 | Synonymous: 30 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 483 | Molecular Weight (kDa): 57.943

UniProt ID(s): Q8I4X2

PDB ID(s): None

Isoelectric Point: 8.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094