Genome location: Pf3D7_12_v3:1,925,058..1,929,618(+)
Genome classification: Core
Product Description: protein KIC4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030121 | AP-1 adaptor complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0140312 | cargo adaptor activity |
| Function | GO:0035615 | clathrin adaptor activity |
| Process | GO:0006896 | Golgi to vacuole transport |
| Process | GO:0006898 | receptor-mediated endocytosis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.10 | 0.54 |
| Trophozoite | expressed | 0.57 | 0.69 |
| Schizont | expressed | 1.76 | 0.28 |
| Gametocyte | expressed | 0.35 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1246300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.684 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4W9
"Best" AlphaFill ligand hit: PE0 (pterine, Local RMSD=0.89) with 5Z79 (Global RMSD=19.59)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 50 | 29 | 74 |
| disruptive | 15 | 77 | 50 | 123 |
| missense | 15 | 77 | 48 | 119 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 101 | 50 | 90 |
| disruptive | 29 | 200 | 75 | 245 |
| missense | 27 | 181 | 64 | 176 |
PlasmoDB Total SNPs: 303
Non-coding: 237 | Synonymous: 42 | Nonsynonymous: 24 | Stop Codon: 0
Protein Length: 888 | Molecular Weight (kDa): 104.015
UniProt ID(s): Q8I4W9
PDB ID(s): None
Isoelectric Point: 8.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013041 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF49348 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |