Genome location: Pf3D7_12_v3:1,936,019..1,937,985(+)
Genome classification: Core
Product Description: pre-mRNA-splicing factor CWC26, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070274 | RES complex |
| Component | GO:0005684 | U2-type spliceosomal complex |
| Component | GO:0005634 | nucleus |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.28 | 0.86 |
| Trophozoite | expressed | 0.50 | 0.71 |
| Schizont | expressed | 0.05 | 0.97 |
| Gametocyte | expressed | 0.54 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1246600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.992 | MFS: -2.016 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1459700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4W6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103002
Most Similar Human Ortholog: Q9BRD0
TM-align score: 0.44 | RMSD: 5.38
Seq Identity: 0.20 | Length: 227 / 390
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137656 | BUD13 homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 14 | 11 | 27 |
| disruptive | 17 | 72 | 48 | 82 |
| missense | 13 | 58 | 40 | 68 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 45 | 10 | 37 |
| disruptive | 43 | 151 | 78 | 133 |
| missense | 24 | 123 | 64 | 82 |
PlasmoDB Total SNPs: 102
Non-coding: 32 | Synonymous: 52 | Nonsynonymous: 18 | Stop Codon: 0
Protein Length: 390 | Molecular Weight (kDa): 46.821
UniProt ID(s): Q8I4W6
PDB ID(s): None
Isoelectric Point: 9.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018609 | Bud13 |
| PFam | PF09736 | Bud13 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |