PF3D7_1246700

Genome location: Pf3D7_12_v3:1,938,255..1,940,352(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.14	0.93
Trophozoite	expressed	0.99	0.50
Schizont	expressed	0.10	0.94
Gametocyte	expressed	0.54	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1246700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.15 | MFS: -3.232 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1459800)

Relative Growth Rate: 0.90 ± 0.12
Confidence: 5.62

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1459800)

Modification: Tagged | RMgm-4972

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4W5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533732

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	24	17	33
disruptive	10	54	42	90
missense	6	41	36	72

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	50	28	47
disruptive	33	139	80	150
missense	17	105	68	90

PlasmoDB Total SNPs: 116

Non-coding: 53 | Synonymous: 43 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 440 | Molecular Weight (kDa): 51.713

UniProt ID(s): Q8I4W5

PDB ID(s): None

Isoelectric Point: 9.53

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR038725	General stress protein, FMN-binding split barrel domain
PFam	PF16242	General stress protein, FMN-binding split barrel domain
Superfamily	SSF50475	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21