Genome location: Pf3D7_12_v3:1,940,990..1,942,955(+)
Genome classification: Core
Product Description: signal recognition particle receptor subunit beta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005785 | signal recognition particle receptor complex |
| Function | GO:0003723 | RNA binding |
| Process | GO:0045047 | protein targeting to ER |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.11 | 0.95 |
| Trophozoite | expressed | 0.68 | 0.61 |
| Schizont | expressed | 0.24 | 0.83 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1246800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.995 | MFS: -2.643 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1459900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4W4
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.32) with 6A8D (Global RMSD=5.82)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103000
Most Similar Human Ortholog: Q9Y5M8
TM-align score: 0.80 | RMSD: 2.37
Seq Identity: 0.25 | Length: 228 / 261
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000144867 | SRP receptor subunit beta |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 24 | 9 | 14 |
| disruptive | 5 | 8 | 6 | 17 |
| missense | 5 | 8 | 6 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 34 | 10 | 14 |
| disruptive | 7 | 37 | 23 | 64 |
| missense | 7 | 25 | 17 | 42 |
PlasmoDB Total SNPs: 86
Non-coding: 71 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 261 | Molecular Weight (kDa): 30.624
UniProt ID(s): Q8I4W4
PDB ID(s): None
Isoelectric Point: 9.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006689 | Small GTPase superfamily, ARF/SAR type |
| InterPro | IPR019009 | Signal recognition particle receptor, beta subunit |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF09439 | Signal recognition particle receptor, beta subunit |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |