PF3D7_1247000 (FBXO9)

Genome location: Pf3D7_12_v3:1,946,545..1,948,824(+)

Genome classification: Core

Function and Localization

Product Description: F-box only protein 9 homolog, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0019005	SCF ubiquitin ligase complex
Component	GO:0005739	mitochondrion
Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	possibly expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1247000.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.152 | MFS: -3.336 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1E5

"Best" AlphaFill ligand hit: PC (phosphocholine, Local RMSD=1.54) with 3UJD (Global RMSD=18.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104095

Most Similar Human Ortholog: V9GZ74

TM-align score: 0.61 | RMSD: 3.49

Seq Identity: 0.15 | Length: 119 / 367

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000112146	F-box protein 9

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	20	16	20
disruptive	3	21	11	57
missense	3	21	11	54

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	43	18	26
disruptive	3	55	36	94
missense	3	51	29	74

PlasmoDB Total SNPs: 112

Non-coding: 103 | Synonymous: 4 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 367 | Molecular Weight (kDa): 44.208

UniProt ID(s): A0A144A1E5

PDB ID(s): None

Isoelectric Point: 9.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036181	MIT domain superfamily
PFam	N/A	N/A
Superfamily	SSF116846	MIT domain superfamily