PF3D7_1247100

Genome location: Pf3D7_12_v3:1,948,855..1,950,984(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.20	0.90
Trophozoite	expressed	0.47	0.72
Schizont	expressed	0.11	0.93
Gametocyte	expressed	0.34	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1247100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.179 | MFS: -2.63 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4W1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156449

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	12	5	15
disruptive	4	36	29	47
missense	4	36	29	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	21	9	15
disruptive	11	82	46	66
missense	10	77	42	57

PlasmoDB Total SNPs: 94

Non-coding: 79 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 247 | Molecular Weight (kDa): 28.561

UniProt ID(s): Q8I4W1

PDB ID(s): None

Isoelectric Point: 6.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A