PF3D7_1247200

Genome location: Pf3D7_12_v3:1,950,501..1,951,542(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.08	0.96
Trophozoite	possibly expressed	0.09	0.94
Schizont	not expressed	0.02	0.98
Gametocyte	expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1247200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: 0.511 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4W0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104276

Most Similar Human Ortholog: Q9H5V9

TM-align score: 0.57 | RMSD: 2.09

Seq Identity: 0.23 | Length: 110 / 174

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000018610	chromosome X open reading frame 56

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	0	12
disruptive	6	18	13	26
missense	6	16	12	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	13	4	12
disruptive	10	44	28	41
missense	7	39	24	31

PlasmoDB Total SNPs: 36

Non-coding: 25 | Synonymous: 0 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 174 | Molecular Weight (kDa): 20.927

UniProt ID(s): Q8I4W0

PDB ID(s): None

Isoelectric Point: 7.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029704	UPF0428 family
PFam	N/A	N/A
Superfamily	N/A	N/A