PF3D7_1247700

Genome location: Pf3D7_12_v3:1,964,582..1,966,234(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.68	0.65
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1247700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: 0.523 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A0Z5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532500

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	17	12	25
disruptive	14	42	33	62
missense	13	42	27	56

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	37	18	36
disruptive	34	97	47	105
missense	24	80	36	71

PlasmoDB Total SNPs: 144

Non-coding: 113 | Synonymous: 17 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 387 | Molecular Weight (kDa): 47.153

UniProt ID(s): A0A144A0Z5

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A