PF3D7_1247900 (UTP11)

Genome location: Pf3D7_12_v3:1,971,796..1,973,538(+)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar RNA-associated protein 11, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Component	GO:0032040	small-subunit processome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.75	0.65
Trophozoite	expressed	0.39	0.79
Schizont	expressed	0.07	0.96
Gametocyte	possibly expressed	0.36	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1247900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.761 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4V5

"Best" AlphaFill ligand hit: AER (abiraterone, Local RMSD=2.75) with 4NKV (Global RMSD=22.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156440

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	8	12	19
disruptive	3	12	7	28
missense	3	12	7	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	23	12	21
disruptive	5	32	17	61
missense	3	27	15	45

PlasmoDB Total SNPs: 102

Non-coding: 93 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 212 | Molecular Weight (kDa): 25.668

UniProt ID(s): A0A144A0U0, Q8I4V5

PDB ID(s): None

Isoelectric Point: 10.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007144	Small-subunit processome, Utp11
InterPro	IPR024930	Skp domain superfamily
PFam	PF03998	Small-subunit processome, Utp11
Superfamily	SSF111384	Skp domain superfamily