PF3D7_1248400

Genome location: Pf3D7_12_v3:1,981,753..1,982,857(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	possibly expressed	0.02	0.99
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	1.12	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1248400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.887 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1461300)

Relative Growth Rate: 1.02 ± 0.16
Confidence: 5.03

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1461300)

Modification: Disrupted | RMgm-4043

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4V0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533571

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	16	7	25
disruptive	14	39	20	61
missense	9	37	20	55

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	37	16	19
disruptive	19	82	35	84
missense	14	70	28	65

PlasmoDB Total SNPs: 61

Non-coding: 16 | Synonymous: 30 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 285 | Molecular Weight (kDa): 34.729

UniProt ID(s): Q8I4V0

PDB ID(s): None

Isoelectric Point: 9.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A