Product Description: bax inhibitor 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.42 | 0.39 |
| Trophozoite | expressed | 1.43 | 0.34 |
| Schizont | expressed | 1.04 | 0.44 |
| Gametocyte | expressed | 1.23 | 0.39 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1248500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.513 | MFS: -2.681 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4U9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100360
Most Similar Human Ortholog: B3KSM0
TM-align score: 0.89 | RMSD: 1.79
Seq Identity: 0.32 | Length: 132 / 289
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135926 | transmembrane BAX inhibitor motif containing 1 |
| ENSG00000155957 | transmembrane BAX inhibitor motif containing 4 |
| ENSG00000178719 | glutamate ionotropic receptor NMDA type subunit associated protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 220
Non-coding: 203 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 2
Protein Length: 289 | Molecular Weight (kDa): 32.275
UniProt ID(s): Q8I4U9
PDB ID(s): None
Isoelectric Point: 8.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006214 | Bax inhibitor 1-related |
| PFam | PF01027 | Bax inhibitor 1-related |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |