About Gene List

PF3D7_1248600

Genome location: Pf3D7_12_v3:1,988,129..1,991,780(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.24 0.88
Trophozoite expressed 0.65 0.64
Schizont expressed 0.22 0.86
Gametocyte expressed 0.54 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1248600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.053 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4U8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156448

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 47 18 51
disruptive 26 116 78 160
missense 20 103 74 146

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 96 30 40
disruptive 53 267 138 275
missense 40 230 113 176

PlasmoDB Total SNPs: 223

Non-coding: 126 | Synonymous: 54 | Nonsynonymous: 43 | Stop Codon: 0

Protein Information

Protein Length: 746 | Molecular Weight (kDa): 87.374

UniProt ID(s): Q8I4U8

PDB ID(s): None

Isoelectric Point: 6.27

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019540 Phosphatidylinositol-glycan biosynthesis class S protein
PFam PF10510 Phosphatidylinositol-glycan biosynthesis class S protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895