PF3D7_1248700

Genome location: Pf3D7_12_v3:1,993,096..2,001,002(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Process	GO:0006338	chromatin remodeling

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	2.37	0.19
Trophozoite	expressed	1.97	0.20
Schizont	expressed	2.03	0.21
Gametocyte	expressed	1.47	0.33

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1248700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.314 | MFS: -2.674 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1461600)

Relative Growth Rate: 0.10 ± 0.17
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4U7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_174451

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	38	108	51	128
disruptive	187	376	146	409
missense	80	245	102	294

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	57	200	74	144
disruptive	270	691	272	636
missense	116	466	185	338

PlasmoDB Total SNPs: 372

Non-coding: 110 | Synonymous: 139 | Nonsynonymous: 123 | Stop Codon: 0

Protein Information

Protein Length: 1989 | Molecular Weight (kDa): 231.318

UniProt ID(s): Q8I4U7

PDB ID(s): None

Isoelectric Point: 6.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596
31390575	Landscape of the Plasmodium Interactome Reveals Both Conserved andSpecies-Specific Functionality.	Hillier C, Pardo M, ..., Choudhary JS	10.1016/j.celrep.2019.07.019