About Gene List

PF3D7_1249000

Genome location: Pf3D7_12_v3:2,004,727..2,007,355(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044228 host cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.10 0.95
Trophozoite expressed 0.17 0.90
Schizont expressed 0.02 0.99
Gametocyte expressed 0.32 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1249000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.13 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4U4

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=2.77) with 6OQ7 (Global RMSD=22.26)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533378

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 38 20 42
disruptive 12 75 33 109
missense 12 72 32 95

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 74 26 53
disruptive 39 142 89 158
missense 29 119 78 126

PlasmoDB Total SNPs: 116

Non-coding: 64 | Synonymous: 34 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 672 | Molecular Weight (kDa): 81.543

UniProt ID(s): Q8I4U4

PDB ID(s): None

Isoelectric Point: 9.83

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
29162636 Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum SurfaceAntigens and Possible Vaccine Candidates. Nilsson Bark SK, Ahmad R, ..., Marti M 10.1074/mcp.RA117.000076