Product Description: THUMP domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005634 | nucleus |
Function | GO:0003723 | RNA binding |
Process | GO:0006400 | tRNA modification |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | expressed | 0.41 | 0.80 |
Trophozoite | expressed | 0.72 | 0.61 |
Schizont | expressed | 0.08 | 0.95 |
Gametocyte | expressed | 0.55 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1249100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.191 | MFS: -2.655 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4U3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102910
Most Similar Human Ortholog: Q9NXG2
TM-align score: 0.52 | RMSD: 3.63
Seq Identity: 0.19 | Length: 214 / 392
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000066654 | THUMP domain containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 25 | 12 | 36 |
disruptive | 15 | 61 | 42 | 69 |
missense | 7 | 48 | 38 | 57 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 10 | 46 | 20 | 42 |
disruptive | 32 | 131 | 47 | 107 |
missense | 16 | 106 | 37 | 65 |
PlasmoDB Total SNPs: 185
Non-coding: 128 | Synonymous: 41 | Nonsynonymous: 16 | Stop Codon: 0
Protein Length: 392 | Molecular Weight (kDa): 44.833
UniProt ID(s): Q8I4U3
PDB ID(s): None
Isoelectric Point: 7.86
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR040183 | THUMP domain-containing protein 1-like |
PFam | N/A | N/A |
Superfamily | SSF143437 | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |