Product Description: protein CutA, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0005507 | copper ion binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.41 | 0.75 |
| Schizont | not expressed | 0.10 | 0.93 |
| Gametocyte | not expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1249500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: 0.852 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1462400)
Modification: Other | RMgm-431
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4T9
"Best" AlphaFill ligand hit: MBO (mercuribenzoic acid, Local RMSD=0.15) with 1NAQ (Global RMSD=1.16)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102193
Most Similar Human Ortholog: O60888
TM-align score: 0.65 | RMSD: 1.25
Seq Identity: 0.43 | Length: 108 / 159
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112514 | cutA divalent cation tolerance homolog |
| ENSG00000226492 | cutA divalent cation tolerance homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 3 | 4 | 18 |
| disruptive | 1 | 25 | 10 | 18 |
| missense | 1 | 25 | 8 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 7 | 12 |
| disruptive | 7 | 48 | 18 | 38 |
| missense | 5 | 41 | 16 | 29 |
PlasmoDB Total SNPs: 147
Non-coding: 131 | Synonymous: 15 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 159 | Molecular Weight (kDa): 18.685
UniProt ID(s): Q8I4T9
PDB ID(s): None
Isoelectric Point: 9.69
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004323 | Divalent ion tolerance protein, CutA |
| InterPro | IPR011322 | Nitrogen regulatory PII-like, alpha/beta |
| PFam | PF03091 | Divalent ion tolerance protein, CutA |
| Superfamily | SSF54913 | Nitrogen regulatory PII-like, alpha/beta |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |