Genome location: Pf3D7_12_v3:2,018,995..2,022,484(-)
Genome classification: Core
Product Description: leucine-rich repeat protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044538 | host cell periphery |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.30 | 0.82 |
| Schizont | not expressed | 0.33 | 0.79 |
| Gametocyte | not expressed | 0.37 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1249600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.256 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A0U1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104917
Most Similar Human Ortholog: Q6ZQY2
TM-align score: 0.69 | RMSD: 3.35
Seq Identity: 0.18 | Length: 313 / 848
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100565 | leucine rich repeat containing 74A |
| ENSG00000187905 | leucine rich repeat containing 74B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 47 | 17 | 54 |
| disruptive | 43 | 120 | 65 | 158 |
| missense | 31 | 94 | 52 | 132 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 80 | 38 | 50 |
| disruptive | 64 | 259 | 131 | 294 |
| missense | 46 | 198 | 102 | 200 |
PlasmoDB Total SNPs: 237
Non-coding: 136 | Synonymous: 56 | Nonsynonymous: 45 | Stop Codon: 0
Protein Length: 848 | Molecular Weight (kDa): 98.686
UniProt ID(s): A0A144A0U1, Q1L698
PDB ID(s): None
Isoelectric Point: 5.19
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001611 | Leucine-rich repeat |
| PFam | PF13516 | Leucine-rich repeat |
| Superfamily | SSF52047 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27777305 | Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. | Davies HM, Thalassinos K, Osborne AR | 10.1074/jbc.M116.761213 |