PF3D7_1249700

Genome location: Pf3D7_12_v3:2,023,076..2,027,563(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1249700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.685 | MFS: -3.119 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1465200)

Modification: Tagged | RMgm-5274

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A118

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532927

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	33	21	41
disruptive	71	117	68	128
missense	25	74	39	83

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	75	30	56
disruptive	119	240	125	265
missense	48	145	81	154

PlasmoDB Total SNPs: 298

Non-coding: 142 | Synonymous: 102 | Nonsynonymous: 38 | Stop Codon: 16

Protein Information

Protein Length: 908 | Molecular Weight (kDa): 105.758

UniProt ID(s): A0A144A118

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A