Genome location: Pf3D7_12_v3:2,029,764..2,040,460(-)
Genome classification: Core
Product Description: THO complex subunit 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000445 | THO complex part of transcription export complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0006406 | mRNA export from nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.85 | 0.61 |
| Trophozoite | expressed | 1.30 | 0.38 |
| Schizont | expressed | 1.16 | 0.41 |
| Gametocyte | possibly expressed | 1.10 | 0.45 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1249800
Resistome Missense Mutations: I1309K
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -3.089 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1462700)
Modification: Other | RMgm-443
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 40 | 157 | 89 | 179 |
| disruptive | 148 | 398 | 216 | 558 |
| missense | 88 | 305 | 176 | 463 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 72 | 303 | 135 | 198 |
| disruptive | 268 | 811 | 410 | 799 |
| missense | 146 | 615 | 325 | 551 |
PlasmoDB Total SNPs: 640
Non-coding: 217 | Synonymous: 232 | Nonsynonymous: 191 | Stop Codon: 0
Protein Length: 2932 | Molecular Weight (kDa): 348.677
UniProt ID(s): Q8I4T6
PDB ID(s): None
Isoelectric Point: 8.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR021418 | THO complex, subunitTHOC2, C-terminal |
| InterPro | IPR040007 | THO complex subunit 2 |
| PFam | PF11262 | THO complex, subunitTHOC2, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |