Genome location: Pf3D7_12_v3:2,043,650..2,044,974(+)
Genome classification: Core
Product Description: rRNA-processing protein FCF2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.47 | 0.77 |
| Trophozoite | expressed | 0.55 | 0.68 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1250000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.389 | MFS: -2.563 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4T4
"Best" AlphaFill ligand hit: JPP (piperacillin (open form), Local RMSD=9.97) with 6H5O (Global RMSD=21.06)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102946
Most Similar Human Ortholog: Q5QJE6
TM-align score: 0.64 | RMSD: 3.72
Seq Identity: 0.16 | Length: 134 / 168
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000067334 | deoxynucleotidyltransferase terminal interacting protein 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 4 | 12 |
| disruptive | 2 | 10 | 9 | 26 |
| missense | 2 | 9 | 9 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 19 | 10 | 16 |
| disruptive | 5 | 27 | 24 | 38 |
| missense | 4 | 23 | 22 | 26 |
PlasmoDB Total SNPs: 62
Non-coding: 52 | Synonymous: 6 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 168 | Molecular Weight (kDa): 19.782
UniProt ID(s): Q8I4T4
PDB ID(s): None
Isoelectric Point: 10.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR014810 | Fcf2 pre-rRNA processing, C-terminal |
| PFam | PF08698 | Fcf2 pre-rRNA processing, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 16762320 | Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved inpre-rRNA processing | Rempola B, Karkusiewicz I, Piekarska I, Rytka J | 10.1016/j.bbrc.2006.05.140 |