About Gene List

PF3D7_1250200

Genome location: Pf3D7_12_v3:2,057,452..2,063,496(+)

Genome classification: Core

Function and Localization

Product Description: CSC1-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005886 plasma membrane
Function GO:0005227 calcium activated cation channel activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.08 0.52
Trophozoite expressed 0.61 0.65
Schizont expressed 1.19 0.48
Gametocyte expressed 0.86 0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1250200

Resistome Missense Mutations: N36I, L800P, S980Y, L984P

Resistome Compounds with Missense Mutations: MMV407834

Resistome # Samples with Disruptive Mutations: 9 (9 missense, 5 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.232 | MFS: -2.7 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4T2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_151021

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 75 32 53
disruptive 53 76 45 116
missense 25 51 33 78

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 122 43 62
disruptive 82 193 64 202
missense 38 114 46 130

PlasmoDB Total SNPs: 386

Non-coding: 287 | Synonymous: 46 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 1039 | Molecular Weight (kDa): 121.331

UniProt ID(s): Q8I4T2

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003864 Calcium-dependent channel, 7TM region, putative phosphate
InterPro IPR027815 10TM putative phosphate transporter, cytosolic domain
PFam PF02714 Calcium-dependent channel, 7TM region, putative phosphate
PFam PF14703 10TM putative phosphate transporter, cytosolic domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104