Genome location: Pf3D7_12_v3:2,064,246..2,066,236(+)
Genome classification: Core
Product Description: vacuolar protein sorting-associated protein 26, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005768 | endosome |
| Component | GO:0030904 | retromer complex |
| Function | GO:0005515 | protein binding |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0042147 | retrograde transport, endosome to Golgi |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.07 | 0.96 |
| Trophozoite | expressed | 0.34 | 0.79 |
| Schizont | expressed | 0.20 | 0.87 |
| Gametocyte | expressed | 0.31 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1250300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.138 | MFS: -2.677 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1463200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4T1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101403
Most Similar Human Ortholog: S4R3Q6
TM-align score: 0.95 | RMSD: 1.47
Seq Identity: 0.51 | Length: 225 / 297
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000122958 | VPS26, retromer complex component A |
| ENSG00000151502 | VPS26, retromer complex component B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 32 | 13 | 27 |
| disruptive | 1 | 3 | 3 | 19 |
| missense | 1 | 2 | 1 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 54 | 17 | 17 |
| disruptive | 3 | 13 | 13 | 53 |
| missense | 1 | 8 | 13 | 38 |
PlasmoDB Total SNPs: 101
Non-coding: 96 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 297 | Molecular Weight (kDa): 34.509
UniProt ID(s): A0A144A4V4, Q8I4T1
PDB ID(s): None
Isoelectric Point: 8.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR028934 | Vacuolar protein sorting protein 26 related |
| PFam | PF03643 | Vacuolar protein sorting protein 26 related |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29654975 | Detection of retromer assembly in Plasmodium falciparum by immunosensing coupledto Surface Plasmon Resonance. | Iqbal MS, Siddiqui AA, ..., Bandyopadhyay U | https://pubmed.ncbi.nlm.nih.gov/29654975/ |
| 32512169 | Rab7 of Plasmodium falciparum is involved in its retromer complex assembly nearthe digestive vacuole. | Siddiqui AA, Saha D, ..., Bandyopadhyay U | 10.1016/j.bbagen.2020.129656 |