About Gene List

PF3D7_1250400

Genome location: Pf3D7_12_v3:2,067,229..2,069,794(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite not expressed 0.15 0.92
Schizont not expressed 0.08 0.95
Gametocyte expressed 1.59 0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1250400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.641 | MFS: -1.329 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4T0

"Best" AlphaFill ligand hit: A3G (3'-deoxy-3'-(glycylamino)adenosine, Local RMSD=0.14) with 5J61 (Global RMSD=16.92)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533020

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 20 20 38
disruptive 23 61 33 100
missense 23 61 31 87

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 57 23 43
disruptive 39 149 69 153
missense 30 127 58 110

PlasmoDB Total SNPs: 100

Non-coding: 51 | Synonymous: 20 | Nonsynonymous: 27 | Stop Codon: 2

Protein Information

Protein Length: 656 | Molecular Weight (kDa): 79.532

UniProt ID(s): Q8I4T0

PDB ID(s): None

Isoelectric Point: 6.32

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104