PF3D7_1250500

Genome location: Pf3D7_12_v3:2,069,903..2,071,659(+)

Genome classification: Core

Function and Localization

Product Description: AP-3 complex subunit sigma, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043231	intracellular membrane-bounded organelle
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.11	0.95
Trophozoite	expressed	0.54	0.68
Schizont	expressed	0.21	0.87
Gametocyte	expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1250500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.158 | MFS: -2.647 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1463400)

Relative Growth Rate: 0.46 ± 0.20
Confidence: 4.56

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1463400)

Modification: Disrupted | RMgm-4049

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A372

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q1JQA3	AP-3 complex subunit sigma-2	Bos taurus	OrthoDB, OrthoMCL BLAST	NSC_11603174

Orthology Information

Ortholog Group (OrthoMCL): OG6_102376

Most Similar Human Ortholog: H0YN38

TM-align score: 0.95 | RMSD: 1.04

Seq Identity: 0.50 | Length: 155 / 157

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000157823	adaptor related protein complex 3 subunit sigma 2
ENSG00000177879	adaptor related protein complex 3 subunit sigma 1

Protein Information

Protein Length: 157 | Molecular Weight (kDa): 18.427

UniProt ID(s): A0A144A372

PDB ID(s): None

Isoelectric Point: 4.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000804	Clathrin adaptor complex, small chain
InterPro	IPR011012	Longin-like domain superfamily
InterPro	IPR016635	Adaptor protein complex, sigma subunit
InterPro	IPR022775	AP complex, mu/sigma subunit
InterPro	IPR027155	AP-3 complex subunit sigma
PFam	PF01217	AP complex, mu/sigma subunit
Superfamily	SSF64356	Longin-like domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 97

Non-coding: 93 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0