Product Description: translation initiation factor eIF-2B subunit beta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.3.1.23 (S-methyl-5-thioribose-1-phosphate isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005851 | eukaryotic translation initiation factor 2B complex |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0006446 | regulation of translational initiation |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.30 | 0.85 |
| Trophozoite | expressed | 0.28 | 0.82 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1250600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.173 | MFS: -2.672 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1463500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1463500)
Modification: Disrupted | RMgm-4050
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4S8
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.3.1.23 | S-methyl-5-thioribose-1-phosphate isomerase | RNAi |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102470
Most Similar Human Ortholog: H0YK01
TM-align score: 0.92 | RMSD: 1.12
Seq Identity: 0.32 | Length: 71 / 679
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000119718 | eukaryotic translation initiation factor 2B subunit beta |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 35 | 19 | 45 |
| disruptive | 15 | 65 | 40 | 89 |
| missense | 13 | 60 | 40 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 81 | 28 | 45 |
| disruptive | 28 | 150 | 62 | 168 |
| missense | 21 | 127 | 56 | 122 |
PlasmoDB Total SNPs: 108
Non-coding: 65 | Synonymous: 23 | Nonsynonymous: 20 | Stop Codon: 0
Protein Length: 679 | Molecular Weight (kDa): 78.752
UniProt ID(s): Q8I4S8
PDB ID(s): None
Isoelectric Point: 7.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000649 | Initiation factor 2B-related |
| InterPro | IPR037171 | NagB/RpiA transferase-like |
| PFam | PF01008 | Initiation factor 2B-related |
| Superfamily | SSF100950 | NagB/RpiA transferase-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |