PF3D7_1250700

Genome location: Pf3D7_12_v3:2,074,635..2,077,593(+)

Genome classification: Core

Function and Localization

Product Description: transcription initiation factor IIA subunit 2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.30	0.80
Schizont	expressed	0.09	0.93
Gametocyte	not expressed	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1250700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.147 | MFS: -3.534 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1463600)

Relative Growth Rate: 0.16 ± 0.12
Confidence: 5.59

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4S7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_202949

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 124

Non-coding: 120 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 177 | Molecular Weight (kDa): 21.276

UniProt ID(s): Q8I4S7

PDB ID(s): None

Isoelectric Point: 7.19

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009088	Transcription factor IIA, beta-barrel
PFam	N/A	N/A
Superfamily	SSF50784	Transcription factor IIA, beta-barrel