PF3D7_1250900

Genome location: Pf3D7_12_v3:2,083,353..2,084,625(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.31	0.85
Trophozoite	expressed	0.72	0.60
Schizont	expressed	0.14	0.91
Gametocyte	possibly expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1250900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -1.446 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4S5

"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=7.10) with 5O0Y (Global RMSD=20.48)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533245

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	19	5	13
disruptive	6	28	19	54
missense	5	26	18	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	30	12	13
disruptive	15	80	29	71
missense	7	65	23	56

PlasmoDB Total SNPs: 54

Non-coding: 26 | Synonymous: 19 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 321 | Molecular Weight (kDa): 38.89

UniProt ID(s): Q8I4S5

PDB ID(s): None

Isoelectric Point: 10.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A