PF3D7_1251000

Genome location: Pf3D7_12_v3:2,085,370..2,086,959(-)

Genome classification: Core

Function and Localization

Product Description: HSP20-like chaperone, putative

SignalP Peptide: MTNILLFFNILWMSTLFVSA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005829	cytosol
Component	GO:0005634	nucleus
Function	GO:0051879	Hsp90 protein binding
Function	GO:0051087	chaperone binding
Process	GO:0051131	chaperone-mediated protein complex assembly
Process	GO:0006457	protein folding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1251000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.985 | MFS: -2.812 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1J3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215366

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	14	5	9
disruptive	3	11	5	23
missense	3	11	5	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	26	9	12
disruptive	5	33	17	47
missense	4	26	15	35

PlasmoDB Total SNPs: 111

Non-coding: 105 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 186 | Molecular Weight (kDa): 21.997

UniProt ID(s): A0A144A1J3

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007052	CS domain
InterPro	IPR008978	HSP20-like chaperone
PFam	PF04969	CS domain
Superfamily	SSF49764	HSP20-like chaperone