About Gene List

PF3D7_1251100

Genome location: Pf3D7_12_v3:2,089,340..2,090,521(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell
Component GO:0005783 endoplasmic reticulum

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.19 0.90
Trophozoite possibly expressed 0.18 0.88
Schizont possibly expressed 0.14 0.90
Gametocyte not expressed 0.12 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1251100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.764 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4S3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532787

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 6 3 8
disruptive 7 33 11 28
missense 7 32 10 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 11 6 13
disruptive 16 60 19 47
missense 14 55 18 30

PlasmoDB Total SNPs: 121

Non-coding: 107 | Synonymous: 3 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 134 | Molecular Weight (kDa): 15.415

UniProt ID(s): Q8I4S3

PDB ID(s): None

Isoelectric Point: 5.81

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31158222 Plasmodium knowlesi as a model system for characterising Plasmodium vivax drugresistance candidate genes. Verzier LH, Coyle R, ..., Rayner JC 10.1371/journal.pntd.0007470