Product Description: coronin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0020039 | pellicle |
| Function | GO:0003779 | actin binding |
| Function | GO:0051015 | actin filament binding |
| Process | GO:0007015 | actin filament organization |
| Process | GO:0048870 | cell motility |
| Process | GO:0007017 | microtubule-based process |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.59 | 0.81 |
| Trophozoite | expressed | 0.10 | 0.95 |
| Schizont | expressed | 1.36 | 0.59 |
| Gametocyte | expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1251200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: -2.201 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1464100)
Modification: Tagged | RMgm-1498
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4S2
"Best" AlphaFill ligand hit: GTG (mrna cap analog n7-methyl gpppg, Local RMSD=0.21) with 5TEF (Global RMSD=2.57)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Homo sapiens | OrthoDB | CHEMBL227622CHEMBL376571CHEMBL325416 |
Ortholog Group (OrthoMCL): OG6_100479
Most Similar Human Ortholog: H3BRJ0
TM-align score: 0.90 | RMSD: 1.54
Seq Identity: 0.27 | Length: 234 / 602
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000102879 | coronin 1A |
| ENSG00000103647 | coronin 2B |
| ENSG00000106789 | coronin 2A |
| ENSG00000110880 | coronin 1C |
| ENSG00000167549 | coronin 6 |
| ENSG00000172725 | coronin 1B |
Protein Length: 602 | Molecular Weight (kDa): 69.015
UniProt ID(s): A0A6F9D4M2, A0A6F9D4T5, A0A6F9D562, A0A6F9D5W5, A0A6F9D643, A0A6F9D676, O44021, Q8I4S2
PDB ID(s): None
Isoelectric Point: 5.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR015048 | Domain of unknown function DUF1899 |
| InterPro | IPR015505 | Coronin |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF08953 | Domain of unknown function DUF1899 |
| PFam | PF16300 | |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 41 | 21 | 35 |
| disruptive | 11 | 32 | 24 | 56 |
| missense | 10 | 30 | 23 | 47 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 71 | 25 | 49 |
| disruptive | 16 | 85 | 42 | 115 |
| missense | 14 | 71 | 34 | 88 |
PlasmoDB Total SNPs: 115
Non-coding: 87 | Synonymous: 19 | Nonsynonymous: 8 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 26187846 | Plasmodium falciparum coronin organizes arrays of parallel actin filamentspotentially guiding directional motility in invasive malaria parasites. | Olshina MA, Angrisano F, ..., Baum J | 10.1186/s12936-015-0801-5 |
| 27409081 | The Actin Filament-Binding Protein Coronin Regulates Motility in PlasmodiumSporozoites. | Bane KS, Lepper S, ..., Frischknecht F | 10.1371/journal.ppat.1005710 |
| 30420498 | Mutations in Plasmodium falciparum actin-binding protein coronin confer reducedartemisinin susceptibility. | Demas AR, Sharma AI, ..., Wirth DF | 10.1073/pnas.1812317115 |
| 33370279 | Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoroninmutants in Plasmodium falciparum. | Sharma AI, Shin SH, ..., Wirth DF | 10.1371/journal.pgen.1009266 |