About Gene List

PF3D7_1251400

Genome location: Pf3D7_12_v3:2,097,053..2,098,971(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.07 0.97
Trophozoite expressed 0.14 0.91
Schizont not expressed 0.02 0.98
Gametocyte possibly expressed 0.17 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1251400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.099 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4S0

"Best" AlphaFill ligand hit: PIN (pipes, Local RMSD=0.24) with 5OFK (Global RMSD=15.61)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533216

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 26 12 26
disruptive 19 42 36 80
missense 11 39 30 75

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 48 18 26
disruptive 26 119 59 94
missense 17 100 49 78

PlasmoDB Total SNPs: 109

Non-coding: 50 | Synonymous: 43 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 469 | Molecular Weight (kDa): 56.53

UniProt ID(s): Q8I4S0

PDB ID(s): None

Isoelectric Point: 9.39

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094