About Gene List

PF3D7_1251600

Genome location: Pf3D7_12_v3:2,102,664..2,105,810(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.80 0.63
Trophozoite expressed 0.43 0.75
Schizont expressed 0.14 0.92
Gametocyte expressed 0.43 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1251600

Resistome Missense Mutations: R366K

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.2 | MFS: -2.79 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1464600)

  • Relative Growth Rate: 1.03 ± 0.15
  • Confidence: 5.24

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1464600)

Modification: Disrupted | RMgm-4053

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4R8

"Best" AlphaFill ligand hit: MXE (2-methoxyethanol, Local RMSD=0.10) with 3TEW (Global RMSD=30.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532846

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 40 23 45
disruptive 36 170 86 143
missense 29 143 74 120

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 19 79 23 53
disruptive 88 306 152 285
missense 66 246 107 162

PlasmoDB Total SNPs: 229

Non-coding: 112 | Synonymous: 63 | Nonsynonymous: 54 | Stop Codon: 0

Protein Information

Protein Length: 712 | Molecular Weight (kDa): 85.411

UniProt ID(s): Q8I4R8

PDB ID(s): None

Isoelectric Point: 9.65

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108