About Gene List

PF3D7_1252500

Genome location: Pf3D7_12_v3:2,145,008..2,147,250(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.96
Trophozoite not expressed 0.03 0.98
Schizont not expressed 0.01 0.99
Gametocyte not expressed 0.26 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1252500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.975 | MFS: -2.692 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A4X8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108399

Most Similar Human Ortholog: Not available

TM-align score: 0.00 | RMSD: 0.00

Seq Identity: 0.00 | Length: / 394

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000197816 coiled-coil domain containing 180

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 19 6 15
disruptive 10 65 31 56
missense 9 60 30 48

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 26 15 28
disruptive 28 122 53 102
missense 25 102 40 56

PlasmoDB Total SNPs: 105

Non-coding: 77 | Synonymous: 7 | Nonsynonymous: 19 | Stop Codon: 2

Protein Information

Protein Length: 394 | Molecular Weight (kDa): 47.312

UniProt ID(s): A0A144A4X8

PDB ID(s): None

Isoelectric Point: 7.48

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12