About Gene List

PF3D7_1252700

Genome location: Pf3D7_12_v3:2,153,221..2,157,441(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044538 host cell periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.18 0.91
Trophozoite expressed 0.61 0.65
Schizont expressed 0.26 0.82
Gametocyte possibly expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1252700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.617 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Q9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131931

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 17 6 21
disruptive 8 34 15 37
missense 8 34 15 33

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 29 13 25
disruptive 16 60 34 104
missense 16 53 32 74

PlasmoDB Total SNPs: 88

Non-coding: 65 | Synonymous: 9 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 450 | Molecular Weight (kDa): 51.984

UniProt ID(s): Q8I4Q9

PDB ID(s): None

Isoelectric Point: 6.38

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25106850 A conserved domain targets exported PHISTb family proteins to the periphery ofPlasmodium infected erythrocytes. Tarr SJ, Moon RW, Hardege I, Osborne AR 10.1016/j.molbiopara.2014.07.011