PF3D7_1252800

Genome location: Pf3D7_12_v3:2,158,574..2,162,555(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.74	0.66
Trophozoite	expressed	0.87	0.54
Schizont	expressed	0.33	0.80
Gametocyte	not expressed	0.09	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1252800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.946 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Q8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532514

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	13	15	22
disruptive	20	55	30	59
missense	18	51	29	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	33	17	32
disruptive	34	108	51	127
missense	30	94	41	75

PlasmoDB Total SNPs: 129

Non-coding: 76 | Synonymous: 25 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 626 | Molecular Weight (kDa): 74.753

UniProt ID(s): Q8I4Q8

PDB ID(s): None

Isoelectric Point: 5.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A