About Gene List

PF3D7_1253000 (GECO)

Genome location: Pf3D7_12_v3:2,166,755..2,170,559(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: gametocyte erythrocyte cytosolic protein

SignalP Peptide: MLLKTSLKNICFLLCVVA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030430 host cell cytoplasm
Function GO:0051082 unfolded protein binding
Process GO:0006457 protein folding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.22 0.89
Trophozoite expressed 0.27 0.86
Schizont expressed 0.08 0.95
Gametocyte not expressed 0.34 0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1253000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: 0.903 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Q6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126097

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 181

Non-coding: 133 | Synonymous: 16 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 469 | Molecular Weight (kDa): 55.682

UniProt ID(s): Q8I4Q6

PDB ID(s): None

Isoelectric Point: 4.53

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001623 DnaJ domain
InterPro IPR026894 DNAJ-containing protein, X-domain
InterPro IPR036869 Chaperone J-domain superfamily
PFam PF00226 DnaJ domain
PFam PF14308 DNAJ-containing protein, X-domain
Superfamily SSF46565 Chaperone J-domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
21965515 Functional analysis of the exported type IV HSP40 protein PfGECO in Plasmodiumfalciparum gametocytes. Morahan BJ, Strobel C, ..., Williamson KC 10.1128/EC.05155-11