About Gene List

PF3D7_1253200

Genome location: Pf3D7_12_v3:2,172,876..2,174,605(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: hypothetical protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.43 0.44
Trophozoite not expressed 0.39 0.79
Schizont not expressed 0.18 0.90
Gametocyte not expressed 0.12 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1253200

Resistome Missense Mutations: I130K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.923 | MFS: -0.281 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Q4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160725

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 53

Non-coding: 37 | Synonymous: 6 | Nonsynonymous: 6 | Stop Codon: 4

Protein Information

Protein Length: 139 | Molecular Weight (kDa): 16.985

UniProt ID(s): Q8I4Q4

PDB ID(s): None

Isoelectric Point: 10.39

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
19765590 Potential epigenetic regulatory proteins localise to distinct nuclearsub-compartments in Plasmodium falciparum. Volz J, Carvalho TG, ..., Cowman AF 10.1016/j.ijpara.2009.09.002